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The antibiotic rifampin (also known as Rifadin and Rimactane) is the only exception — it can lower the effectiveness of the pill, patch, and ring The antifungal medicine griseofulvin can impact birth control hormones. Here is a link for your resourceful learning; https://www. Augmentin doesn't decrease the effectiveness of the Nexplanon implant because there is no drug interaction between them. Does Augmentin interact with my birth control, Gianvi? Specific anticonvulsants and seizure drugs can interfere with birth control, including carbamazepine (Tegretol), phenytoin (Dilantin), primidone (Mysoline), and phenobarbital. Ask your doctor about using a non-hormonal birth control (condom, diaphragm, cervical cap, or contraceptive sponge) to prevent pregnancy. This causes the birth control to fail because the hormone levels are reduced and become less effective. Augmentin can make birth control pills less effective. 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