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15 mg/kg IV, with the first dose (infused over 15 minutes) 30 minutes before the start of emetogenic chemotherapy and subsequent doses given 4 and 8 hours after the first dose. Zofran can be taken with or without food. These data were combined with sequential pharmacokinetics data from 41 surgery patients 1 month to 24 months of age, who received a single dose of 0. Plasma protein binding of ondansetron as measured in vitro was 70% to 76% over the concentration range of 10 to 500 ng/mL. For patients ages 12 and older, the dosage is the same as for adults. The first dose is usually taken before the start of your surgery, chemotherapy, or radiation treatment Dosage in Hepatic Impairment In patients with severe hepatic impairment (Child-Pugh score of 10 or greater), do not exceed a total daily dose of 8 mg [see Use in Specific Populations (8. V 3 DOSAGE FORMS AND STRENGTHS ZOFRAN tablets are oval, film-coated tablets engraved with “Zofran” on one side and are available in the following strengths: 4 mg – white tablet with “4” engraved on the other side. No reduction in dose or dosing frequency in these patients is warranted. Administration Instructions for ZOFRAN ODT Orally Disintegrating Tablets. Follow all directions on your prescription label. Zofran, a brand-name version of Ondansetron, is available by prescription in tablet form in different strengths. For treatment of established PONV, administration by injection is.. Indications & Dosage Zofran coupons. ZOFRAN oral solution contains the inactive ingredients citric acid anhydrous, purified water, sodium benzoate, sodium citrate, sorbitol, and strawberry flavor. Do not take this medicine in larger or smaller amounts or for longer than recommended. Blurred vision or temporary vision loss (lasting from only a few minutes to several hours); high levels of serotonin in the body--agitation, hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, fainting. Comments: Multi-day, single-dose administration of 24 mg orally for HEC has not been studied Your doctor may change the dosage and prescription of ZOFRAN to get you the best results possible. Dosage in Hepatic Impairment In patients with severe hepatic impairment (Child-Pugh score of 10 or greater), do not exceed a total daily dose of 8 mg [see Use in Specific Populations (8. Four- and 8-mg doses of either ZOFRAN Oral Solution or ZOFRAN ODT Orally. Dosage & Administration See full prescribing information for the recommended dosage in adults and pediatrics. Ondansetron every 4 hours for 3 doses during a safety and efficacy trial. 15 mg/kg over 15 min administered 30 min before chemotherapy, then 4 and 8 hr after first dose; not to exceed 16 mg (32 mg no longer recommended because of increased risk of QT prolongation). Administration Instructions for ZOFRAN ODT Orally Disintegrating Tablets Do not attempt to push ZOFRAN ODT tablets through the foil backing Take Zofran exactly as prescribed by your doctor. In patients with severe hepatic impairment (Child-Pugh score of 10 or greater), do not exceed a total daily dose of 8 mg [see Use in Specific Populations (8. Common ondansetron side effects may include:. For those ages 4 to 11, patients should take a 4-mg tablet or rapidly disintegrating tablet or 5 mL of liquid three times per. · Zofran tablets are indicated for the prevention of post-operative nausea and vomiting (PONV). ( 2) Patients with severe hepatic impairment: do not exceed a total daily dose of 8 mg. Circulating drug who can buy metformin online also distributes into erythrocytes. 15 mg/kg/dose IV q4h x3 doses; Start: 30min before chemo; Max: 16 mg/dose. Comments: Multi-day, single-dose administration of 24 mg orally for HEC has not been studied received a dose of 0. Each 5 mL of ZOFRAN oral solution contains 5 mg of ondansetron hydrochloride dihydrate equivalent to 4 mg of ondansetron. Dosage forms: TAB: 4 mg, 8 mg; SOL: 4 mg per 5 mL; INJ: various nausea/vomiting prevention, chemo-related [IV route, highly- or moderately-emetogenic chemo, 6 mo and older] Dose: 0. Zofran is a medication used to prevent nausea and vomiting caused by cancer chemotherapy, radiation therapy, or surgery 2022. Administration Instructions for Zofran ODT Orally Disintegrating Tablets. 8 mg – yellow tablet with “8” engraved on the other side Peds Dosing.

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